Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase
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چکیده
منابع مشابه
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Amyloid precursor protein (APP) is endoproteolytically processed by BACE1 and gamma-secretase to release amyloid peptides (Abeta40 and 42) that aggregate to form senile plaques in the brains of patients with Alzheimer's disease (AD). The C-terminus of Abeta40/42 is generated by gamma-secretase, whose activity is dependent upon presenilin (PS 1 or 2). Missense mutations in PS1 (and PS2) occur in...
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Alzheimer's disease (AD) is characterized pathologically by an abundance of extracellular neuritic plaques composed primarily of the 42-amino acid amyloid β peptide variant (Aβ42). In the majority of familial AD (FAD) cases, e.g., those harboring mutations in presenilin 1 (PS1), there is a relative increase in the levels of Aβ42 compared to the levels of Aβ40. We previously reported the charact...
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15 صفحه اولEffect of Continuous and Interval Training on Amyloid β 42 (Aβ42) and Malondialdehyde (MDA) Levels in Hippocampus of Elderly Rats
Introduction: Amyloid plaques in the brain increase with age. Thus, the present study aimed to evaluate the effect of continuous and interval training on Amyloid β 42 (Aβ42) and Malondialdehyde (MDA) levels in hippocampus of elderly rats. Methods: The present study was experimental one with two experimental groups and one control group. Thirty old male Wistar rats (18 weeks-old) divided into 3...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2003
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddh019